Females found to itch less than males

Inflammation of the skin is found in ovarian estradiol deficiency in mice. Credit: KyotoU / Global Comms

One of the many reasons men can get jealous of women, at least when it comes to skin inflammation, is that women are less likely to develop severe psoriasis. However, the exact cause of sexual differences has not been determined.

Now, a team of researchers has found that the female hormone estradiol prevents psoriasis, and the protective function of the hormone provides a basis for the possibility of a cure.

“Our results not only explain genetic pathways sexual differences in psoriasis but also sheds new light on our understanding of estradiol sedation, ”said Tetsuya Honda of Hamamatsu University School of Medicine, formerly Kyoto University.

The group tested rats, or cko mice, with removal of the ovaries but supplemented with estelleiol pellets or placebo. Unlike rats, cko mice without estradiol of natural ovarian hormones show no signs of severe disease. skin inflammation.

Once estradiol mice are released, the production of IL-17A and IL-1β cytokines in neutrophil and macrophage. antibiotics is rotated, reducing inflammation. This effect has also been observed in human neutrophils in vitro.

What surprised researchers was how the lack of isrogen receptors in the immune system caused estradiol to become less effective on cytokines.

“These results suggest that estradiol inhibits psoriatic inflammation by regulating neutrophil and macrophage levels,” the author said.

The paper, “Estradiol prevents psoriatic inflammation in mice by regulating neutrophils and macrophage activity, ”stated on May 4, 2022 in Journal of Allergy and Clinical Immunology.

Comparison of contraceptives reveals differences in the negative impact of survival between different estrogen compounds

Learn more:
Akimasa Adachi et al, Estradiol inhibits psoriatic inflammation in mice by regulating the activity of neutrophil and macrophage, Journal of Allergy and Clinical Immunology (2022). DOI: 10.1016 / j.jaci.2022.03.028

hint: Minor women found (2022, June 24) Returned on June 24, 2022 from

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