Fecal transplants reverse hallmarks of aging

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In the pursuit of eternal youth, poo transplantation may seem like an impossible way to change the aging process.

However, scientists at the Quadram Institute and the University of Eastern Anglia provide evidence, from research inside berayethat transplant fecal microbiota from young to old rats may reverse the signs of aging in the intestines, eyes, and brain.

In a previous experiment, smallpox cells from older mice caused inflammation in the brains of young receptors and reduced the essential protein required for normal vision.

These findings suggest that gut pathogens play a role in regulating certain factors that cause aging and open the possibility of antimicrobial therapies to address relapses in later life.

Professor Simon Carding, of the UEA School of Medicine in Norwich and head of the Gut Microbes Research Center and the Quadram Institute of Public Health, said: directly in aging and reduced brain function. working with vision and offering possible solutions through antimicrobial therapy. “

It has been known for some time that the amount of bacteria we carry in the intestine, along with the so-called internal microbiota, is related to health. Most diseases are associated with changes in the types and characteristics of bacteria, viruses, fungi and other micro-organisms in the human intestine.

Some of these changes in the microbiota occur as we age, have a detrimental effect on metabolism and immunity, and this is related to age-related diseases including inflammatory bowel disease, with heart disease, autoimmune, metabolism and neurodegenerative diseases.

To better understand the impact of these changes on the microbiota in aging, scientists from the Quadram Institute have modified the change. microbes from old mice to healthy mice, and vice versa. They then looked at how this affected the symptoms of inflammation of the intestines, brain and eyes, which suffer from decreased function in later life.

The study, published in the journal Microbiomefound that microbiota from older donors resulted in a loss of integrity of the gut lining, allowing bacterial samples to enter the circulation, leading to bacterial overgrowth. immune system and inflammation in the brain and eyes.

Chronic inflammation associated with age, also known as inflammation, is associated with the activation of specific antibodies found in the brain. These cells are also widely used in small mice that have received adult microbiome transplants.

In the eye, the team also found specific proteins associated with eye damage were elevated in mice that received the microbiota from older donors.

In older mice, these malignant changes in the intestine, eye and brain can be reversed by implanting gut microbiota from small mice.

In ongoing studies, the team is now working to understand how long these positive effects can last, and to identify the beneficial effects of microbiota contributing and how they affect organs far away. gut.

Microbiota of small mice, as well as older mice that received small amounts of microbiota enriched themselves with beneficial pathogens that were previously linked. health in mice and humans.

The researchers also studied the products produced by these bacteria by breaking down the nutrients in our food. This identifies major changes in lipids (fats) and vitamin metabolism, which may be related to changes observed in inflammatory cells in the eye and brain.

Such mechanisms exist in humans, and the human microbiota is also highly variable in future life, but researchers are cautious about exerting their effects directly on humans until such a study is conducted in older people.

A new facility is being built for Microbiota Transplantation (MRT), also known as Fecal Microbiota Transplantation (FMT) in the Quadram Center which will facilitate such experiments, as well as other tests for microbiota-related conditions.

Lead author of the study, Dr. Aimee Parker from the Quadram Institute, said: “We are pleased to discover that by altering the microbiota of the gut gut of the elderly, we can save the associated age-related decline seen in eye damage and brain damage. brain.

“Our findings provide further evidence of a significant link between microbes in the gut and the optimal aging of tissues and organs around the body. We hope that our research will ultimately contribute to understanding how we can manage our diet. and our bacteria to improve overall health. in the future. “

“Alteration of fecal microbiota between young and old mice alters aging symptoms of gut, eye, and brain” published in the journal. Microbiome.

Gastrointestinal bacteria reverse the aging process in mice

Learn more:
Aimée Parker et al, Fecal microbiota Transfer between young and old mice reverses signs of aging of the gut, eye, and brain, Microbiome (2022). DOI: 10.1186 / s40168-022-01243-w

hint: Internal Reversal of Aging Signs (2022, May 4) Retrieved 4 May 2022 from

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