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FDA expected to authorize mix-and-match COVID booster shots – Press Telegram

Sieg Miller

Washington (AP) —Federal regulators are expected to approve COVID-19 booster dose mixing and matching this week to provide flexibility as the campaign for additional shots expands.

The next announcement by the Food and Drug Administration is likely to come with the approval of Moderna and Johnson & Johnson Shot boosters, following the OK of the third dose of Pfizer vaccine to many Americans last month. The move was previewed Tuesday by US health officials familiar with issues that were not allowed to speak publicly prior to the announcement.

The FDA was expected to say that it was still preferable to use the same brand for boosters, especially for Pfizer and Modana mRNA vaccines, which have proven to be most effective against coronavirus. The agency was still finalizing the guidance for the Single Shot J & J Vaccine.

Preliminary results from government studies on various booster combinations have found that additional doses of all types increase the level of antibodies that fight the virus, regardless of the brand that people first received. However, single-dose J & J vaccination recipients showed the most dramatic response. Antibody levels increased 76-fold and 35-fold immediately after the Moderna or Pfizer booster, respectively, compared to the 4-fold increase after the second J & J. shot.

One of the confusing decisions is the dose recommended by Moderna in combination with other brands. Moderna has applied for a booster to halve the original dose. This is enough for those who have already taken two full-strength shots. However, mixed-and-match studies use full-strength additional doses, and there is no way to know if half-dose Modana boosters provoke a strong response to J & J recipients.

FDA expected to authorize mix-and-match COVID booster shots – Press Telegram Source link FDA expected to authorize mix-and-match COVID booster shots – Press Telegram

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