Exploring dynamics of blood flow in vascular, atherosclerotic diseases

3D reconstruction of the carotid artery stenosis, the diameter and flow rate at the inlet and outlet (left) and 3D printed simulation model (right). Credit: Zhiyong Song, Pengrui Zhu, Lianzhi Yang, Zhaohui Liu, Hua Li, and Weiyao Zhu

Medical practices, such as improving diet, lowering blood lipids, or controlling high blood pressure and blood sugar, can do much more when it comes to treating atherosclerotic disease. Is it possible to predict in advance the risk factors for the formation of plaque in the carotid arteries by characteristics of the vascular system and high blood pressure before the disease progresses?

Inside Physics of Fluids, Researchers in China have presented doctors with data on the risk factors for the formation of atherosclerotic plaque from mechanical scales. Scientists are investigating whether it is possible to diagnose and intervene early for people at risk for atherosclerotic disease from a hemodynamics perspective, using Doppler color ultrasound, coronary heart disease computed tomography angiography, and other tests.

“Carotid endarterectomy and carotid artery stenting are the main methods used to treat coronary heart disease,” said Zhiyong Song, of Beijing University of Science and Technology. “Changes in the vascular system after exercise and water engineers They are essential for restenosis, so determine how to reduce the size dangers postoperative flow is essential for improvement therapeutic effect. “

Researchers have developed a method of measuring non-invasive laser flow called microparticle image velocimetry (Micro-PIV), something they say has continued to improve over the past few decades and has exceed technology limits by one point.

“It can record fast data distribution over a wide range of space in this temporary environment to provide a comprehensive space system and flow characteristics,” Song said.

The researchers found a large gap between their study and the clinical approach in terms of wall fractional computation, which can lead to confusion about the mathematical model.

“Depending on the subdivision — such as the velocity field in the central carotid stenosis — indicated by Micro-PIV and simulations, the current clinical evaluation method of wall stress at the site of stenosis may result in differences up to 60 %, “said Song.

The hemodynamic study of the carotid atherosclerotic plaque group is of clinical importance for understanding the formation and development of the system. atherosclerotic diseasesimproving surgical techniques, and researching and developing advanced medical devices.

Computer-assisted imaging of atherosclerosis in the carotid artery

Learn more:
Studies on the distribution of radial segmental velocity and wall severity associated with carotid artery stenosis, Water Physics (2022). DOI: 10.1063 / 5.0085796

hintInvestigate blood pressure in arteries, atherosclerotic disease (2022, May 10) retrieved May 10, 2022 from html

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