Exercise shown to release protein reducing bowel cancer risk

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Graphic design. Credit: World Journal of Cancer (2022). DOI: 10.1002 / ijc.33982

Scientists at the University of Newcastle have shown that exercise stimulates the production of cancer-fighting protein, interleukin-6 (IL-6), into the bloodstream which helps repair the DNA of damaged cells.

The results of the study, published in World Journal of Cancerprovides new insights into the role of moderate activity in the fight against chronic illness and may help to improve treatment in the future.

DNA repair

Dr Sam Orange, a professor of physical education at the University of Newcastle, said: “Previous scientific evidence has shown that more than that. work out it is better to reduce intestinal ulcer risk as most physical activity people do, reducing the chances of getting it. Our findings support this view.

“When exercise is repeated several times each week over a longer period of time, cancer-causing factors — such as IL-6 — released into the bloodstream are more likely to interact with non-cancer cells. they do well, repair their DNA and reduce the risk of cancer. “

In small readingwhich is proof of theory, a team from Newcastle and York St John universities hosted 16 men aged 50-80, all of whom had life-threatening conditions for colon cancer, such as obesity or not exercise.

After providing the first blood sample, participants cycled on indoor bikes for 30 minutes on average and a second blood sample was taken as soon as they finished the exercise.

As a control measure, on a separate day, scientists took additional blood samples before and after the participants rested. Tests were performed to see if exercise altered the amount of anti-cancer proteins in the blood compared to rest products and found that there was an increase in IL-6 protein.

Scientists added blood samples to the cancer cells in the laboratory and monitored cell growth for more than 48 hours. They found that blood samples collected directly after exercise slowed growth. cancer cells compared to those collected during the holidays.

Furthermore, as well as reducing cancer growth, exercise blood sample minimizes DNA damage, suggesting that physical activity can repair cells to form cell types.

Dr Orange said: “Our research is very interesting because they uncovered a newly discovered mechanism related to how exercise reduces the risk of colon cancer that does not depend on weight loss.

“A better understanding of these approaches can help provide better exercise guidelines for cancer prevention. It may also help to develop drugs that mimic other health benefits of exercise.

“Exercise of any kind, at any time, can improve the health and reduce the risk of colon cancer but more than ever it is good. People who live in peace should start by exercising body and look to build physical function in daily activities. “

Dr. Adam Odell, Senior Lecturer in Biosciences from York St John University, who also participated in the study with Dr. Alastair Jordan and Dr. Owen Kavanagh, adds: “Importantly, it is not just bowel cancer that can be can reduce it by. guide more m salon. There is a clear association between higher exercise levels and a lower risk of developing certain cancers, such as breast cancer and endometrium.

“By implementing a way in which regular physical activity can have a positive impact on cancer, our research provides additional support for current national and global efforts to increase physical activity.”

Cancer of the intestine

Bowel cancer is the 4th most common cancer in the UK, accounting for 11% of all new cases cancer times. There are about 42,900 people infected in the UK each year, about 120 every day.

It is estimated that physical activity reduces the risk by almost 20%. This can be done by going to the gym, playing sports or going on an active trip such as walking or cycling for work, but also as part of a housework or chores such as gardening or cleaning.

The team intends to continue research to find out exactly how exercise reduces DNA damage in primary cancers and to establish the most effective exercise system to protect against the disease.

The impact of strenuous exercise in humans on cancer progression

Learn more:
Samuel T. Orange et al, Intravenous motor neurons reduce the proliferation of cancer cells in vitro by interleukin-6-induced DNA damage, World Cancer Journal (2022). DOI: 10.1002 / ijc.33982

hintExercise has been shown to release protein that reduces the risk of colon cancer (2022, April 7) Retrieved 7 April 2022 from

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