Elevated inflammation persists in immune cells months after mild COVID-19

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There is a lack of understanding of why some people experience symptoms long after exposure to COVID-19. A new study from the Karolinska Institute in Sweden, the Helmholtz Munich University (HMGU) and the Munich University of Technology (TUM), both in Germany, now show that a type of anti-viral drug called macrophages is showing inflammation changes and life span for several months. after simple COVID-19. The results of the study were published in the journal Mucosal Immunology.

“We can show that macrophages from individuals with mild COVID-19 show a marked change in inflammation and life span for three to five months after infection,” said Craig Wheelock, docent at the Department of Biology and Biophysics. , Karolinska Institutet, and one. of the study authors. “While most of these people have no signs of progress, their immune systems are healthier than their peers.”

Long-term symptoms are common after severe COVID-19 infection but can also affect some people with back pain. Further research is needed to understand long-term immune crises in patients who have recovered from a severe period of infection.

To investigate this area, researchers in the present study examined blood samples from 68 people who had been exposed to COVID-19 in the past and a group of 36 people who did not have COVID-19.

The researchers isolated macrophages in the laboratory and strengthened them with increase protein, steroids and lipopolysaccharides (LPS), molecules that trigger the immune system. The cells are then subjected to RNA to measure active cells. The researchers also measured the presence of eicosanoid signaling pathways, which have important features kumburi.

“It is not surprising that large amounts of eicosanoid cells are found in people with COVID-19 when the disease causes inflammation, but it is surprising that they are still produced several months after infection. disease, ”said Craig Wheelock.

Studies also show high levels of leukotrienes, which are a type of bacterium that causes asthma.

“It is very surprising that the amount of leukotrienes is so high in it macrophages among people who have found simple COVID-19, “said study author Julia Esser-von Bieren, president of the research team at the Helmholtz Munich Institute and the Munich University of Technology.” Leukotrienes are major mediators of asthma, but also they are the mediators of asthma. involved in the antiviral defense against influenza. Long-term improvement after SARS-CoV-2 infection may result in higher susceptibility to respiratory inflammation, but it may also increase immunity to SARS-CoV-2 or other viruses. ”

The blood sample They were collected twice, at three to five months after SARS-CoV-2 infection and after 12 months. At three to five months, almost 16 percent reported progressive symptoms while the others have no clue. At 12 months, no one reported any signs of progress and there was no difference alamomin kumburi between those with previous COVID-19 infection and the health care group.

The researchers noted that COVID-COVID was not investigated specifically in the study and therefore further research is needed to determine whether these results may be directly related to what is also known as long-term COVID.

Esser-von Bieren said: “We would like to make a comprehensive study in which we would include people who have severe COVID-19 and people who do not have COVID-19 but who have some form of respiratory disease. , like a cold, “said Esser-von Bieren. “We will then investigate whether the substance that causes COVID-19 infection in patients is also contagious.

The development of ‘immune deficiencies’ can lead to respiratory failure after COVID-19

Learn more:
M COVID-19 binds to long-term inflammatory eicosanoid- and chemokine receptors in monocyte derived macrophages, Mucosal Immunologyonline March 15, 2022, DOI: 10.1038 / s41385-021-00482-8

hintInflammation continues in the immune system months after simple COVID-19 (2022, March 14) was recovered on 14 March 2022 from -cells.html

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Elevated inflammation persists in immune cells months after mild COVID-19 Source link Elevated inflammation persists in immune cells months after mild COVID-19

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