Dynamic cells linked to brain tumor growth and recurrence

Collagen 1, a protein produced by bacteria, is essential for the growth and function of these viruses. Credit: Pedro Lowenstein

Cancer is made up of many different types of cells, both cancer cells and patients. Specific cell lines in tumor cells are a hallmark of the disease, which makes treatment difficult. While scientists have long known the types of cells involved in tumor cell growth, the mechanisms by which these tumors grow depend on the understanding that cells are weak, immobile and regulated.

But researchers at the University of Michigan Rogel Cancer Center have found that these acute tumors they consist of highly active cells that move in tissue in complex patterns. What’s more, a collection of these tall, smooth-like cells found in the tumor, created on ‘oncostreams,’ form the basis of cancer cells, determining how tumor growth and invasion occur. regular meat.

Pedro Lowenstein, MD, Ph.D., Richard C. Schneider Collegiate Professor of Neurosurgery and lead author of this study at Environmental communicationhe said this planned development is the reason brain pain so sensitive.

“Brain cancer is highly lethal, with less than 5% of patients living more than five years,” he said. “Unfortunately, recurrence is what eventually kills patients. They are operated on for the first increase, but the pain usually returns within 12 to 18 months,” he said.

Lowenstein and his team, including Maria Castro, Ph.D., also found that the excess and strain of Collagen 1, a protein produced by tumor cells, is important for the growth and function of these features.

“When we eliminated the production of Collagen 1 from cancer cellsthe animal model with computer tumors have lived a long time. This level eliminates cancer from the tumor and reduces the risk of cancer because tumors need Collagen 1 to move in the specific way we have identified, ”Lowenstein said.

Lowenstein said this system may be present in some types of cancer, too. “Once people realize that there are strong areas of the virus, and they are related grow biggerinvasion and death from the end, people will be able to find drainage in other forms of flooding, ”he said.

To find out this unknown presence of oncostreams, the team teamed up with Todd Hollon, MD, assistant professor in the Michigan Department of Physiology, and Sebastien Motsch, Ph.D., professor of mathematics at Arizona State University , for temporary implementation. intelligent methods for identifying features in tissue.

“Essentially, we show images to a computer and eventually the computer learns to recognize what’s going on,” Lowenstein explains.

Disrupting waterways by eliminating Collagen 1 may represent a novel therapeutic purpose to treat dying brain cancer. “This study confirms the importance of continuing to explore the complex matrix,” said Andrea Comba, Ph.D., research fellow and lead author of the study.

“Based on this study, we recommend targeting tumors to disperse the waves, and as a new treatment for cerebral glioma,” she said.

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Learn more:
Andrea Comba et al, Spatiotemporal study of glioma heterogeneity shows COL1A1 as an active target for disrupting tumor growth, Environmental communication (2022). DOI: 10.1038 / s41467-022-31340-1

hintStrong genes associated with increased brain inflammation and recurrence (2022, June 28) were recovered June 28, 2022 from -tumor.html

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