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Dog coronavirus jumps to humans, with a protein shift

Virus (2022). DOI: 10.3390 / v14050853 “width =” 800 “height =” 318 “/>

A good choice, special amino acid conversions and GARD components tailored to the CCoV-HuPn-2018 increased area map [3]. S1 and S2 proteins are illuminated and further subdivided into functional groups and subgroups. Blue dots represent tabs under improved selection in CCoV-HuPn-2018 as identified by MEME and / or FEL; red dots represent a group of sites that are unique in CCoV-HuPn-2018 but are not subject to validation; yellow dots are meaningless changes between CCoV-HuPn-2018 and HuCCoV_Z19Haiti. The scripts accompany each active area / area: SP, peptide signal; 0 area; Regional area; B, includes RBD-Receiver-Binding Domain; C; D; UH, helicopters; FP, fusion peptide; HR1, heptad-repeater 1; CH, center helix; BH, gashi-hair; CD: connecting area; HR2, heptad-repeater 2; TM, transmembrane region; CT, cytoplasmic tail. The horizontal magenta channel represents the area tested for the binding of sialic acid in the TGEV [11,37]. The vertical black lines represent GARD break points that are not reconnected and are labeled. The vertical dashed line represents the end of step 3 ‘of setup I and the beginning of FCoV2 homology (set of stage II). Credit: Bacteria (2022). DOI: 10.3390 / v14050853

Researchers at Cornell University have identified a mutation in the canine coronavirus that may indicate signs of transmission from animals to humans.

A new canine coronavirus was first identified in two Malaysian patients who contracted pneumonia in 2017-18. A team of other scientists identified, coronavirus canine, listed, and published their findings in 2021.

Now, a team led by researchers from Cornell and Temple University has discovered a process that takes place at the end of the vascular bundle – an area of ​​the vas deferens that easily penetrates host cell. This process shows the virus is changing from intestinal and respiratory systems of animals to infection of the respiratory system only in host.

The researchers discovered a mutation in the terminal — commonly known as the N terminus — of the genes with mutations and was detected in a coronavirus, which flew from bats to humans, causing influenza. .

“This study identified some of the molecular mechanisms With a strong migration from coronavirus protection to a new host of humans, this could be a major factor in the proliferation of new coronavirus that we previously did not know about, “said Michael Stanhope, a professor of public health and the environment at Cornell. First author, Jordan Zehr, is a graduate student at Temple University. The paper is published in the journal Bacteria.

In the study, the researchers used modern evolutionary tools to determine how much pressure from natural selection may influence the evolution of the canine coronavirus’.

Similar variants of the canine coronavirus found in Malaysia and were reported in 2021 in a small number of people in Haiti, who also have respiratory illnesses.

Stanhope believes that more research is needed to understand if the virus changes and jumps to humans occurs suddenly in different parts of the world or if this coronavirus has been roaming for perhaps several years. in the population without detection.


‘Dog coronavirus found in humans’ – why not worry


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Jordan D. Zehr et al. Bacteria (2022). DOI: 10.3390 / v14050853

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Cornell University

hintDog coronavirus jumps in humans, with protein mutation (2022, May 3) restored May 3, 2022 from https://medicalxpress.com/news/2022-05-dog-coronavirus-humans-protein-shift.html

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