Health

Disease severity linked to N protein of SARS-CoV-2

From left: Sharif M. Hala, Sara Mfarrej, Professor Arnab Pain, Muhammad Shuaib and Tobias Mourier (not pictured) study the SARS-CoV-2 protein N to better understand its role in chronic disease. Credit: King Abdullah University of Science and Technology

Several studies following the spread of SARS-CoV-2 in Saudi Arabia have identified mutations in the protein N virus associated with bacterial proliferation in COVID-19 patients. The study sheds light on the activity of this nucleocapsid protein, which may help improve the effectiveness of drugs that reduce the risk of coronavirus infection.

“Nucleocapsid protein (N) is the most abundant protein in all coronaviruses, including SARS-CoV-2,” said KAUST scientist Muhammad Shuaib. This protein binds to different parts of the RNA virus, affecting its accumulation in bacteria. It also plays a role in host host cells copy virus and immune responses.

The researchers, working with Arnab Pain, found that two in a row replacement in protein N, called R203K and G204R, are associated with increased COVID-19 intensity in patients. Studies have shown that changes in proteins cause it to bind more strongly to RNA.

Further experiments in laboratory cells have shown that changes in N proteins allow the virus to more effectively steal the cell translation machine to facilitate the copying of bacteria. They have also been linked to increased expression of interferon-containing molecules and chemokine production. This may be after a life-threatening cytokine attack that occurs in some COVID-19 patients, causing them to suffer greatly.

The results of the study were the result of a series of bacterial studies from 892 patient samples taken from different parts of Saudi Arabia between March and August 2020, comparing the onset of the disease. This was followed by a comparison of patient data to understand how mutations affect the pathogenesis and pathogenesis.

“Compared to high-density lipoprotein, protein N is highly regulated in various coronaviruses, such as SARS and MERS; however, attempts to develop a vaccine have not been successful,” said Tobias Mourier, a leading research scientist. and counseling working in the Pain team. “Understanding the function of N proteins may contribute to the development of targeted drugs and may limit the severity of the disease in COVID-19 and other coronavirus infections.”

The research team led by KAUST, which includes scientists and doctors from institutions and hospitals across Saudi Arabia, continues to monitor SARS-CoV-2 infection across the country with observation of intoxication the spot affects the host’s interaction under different immune systems. “The effects of genetic predisposition and the reporting of genetic mutations from regions of the world that are not fully represented in the current data are important for the monitoring and evaluation of new stress variables,” he said. Pain.


Research has identified the potential use of SARS-CoV-2 drugs


Learn more:
Tobias Mourier et al, SARS-CoV-2 genomes from Saudi Arabia induce nucleocapsid replacement in host response and bacterial proliferation, Environmental communication (2022). DOI: 10.1038 / s41467-022-28287-8

hintThe SARS-CoV-2 protein N virus (2022, March 28) was recovered 28 March 2022 from https://medicalxpress.com/news/2022-03-disease-severity-linked-protein-sars -cov- .html

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Disease severity linked to N protein of SARS-CoV-2 Source link Disease severity linked to N protein of SARS-CoV-2

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