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Discovery of crucial protein boosts hopes of preventing type 1 diabetes

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Australian researchers may be a step closer to preventing type 1 diabetes after discovering an important protein that can prevent autoimmune disease from taking place.

The University of Queensland and Mater researchers have developed a natural agentsRAGE, which promotes cognitive function, which is impaired in people who develop type 1 diabetes diabetes.

Type 1 diabetes is a life-threatening condition in which the pancreas produces little or no insulin.

UQ Faculty of Medicine researcher, Professor Josephine Forbes says protein discovery is an exciting development.

Our laboratory tests have shown that sRAGE can correct T-cell cell defects for the best prevention of the disease. immune system from taking haywire and causing diabetes, ”says Professor Forbes.

“Our pre-hospital research has shown that this agent will be safer and less invasive than that current treatment It is tested for type 1 diabetes, such as T-cell infusion.

“We have already started working with companies overseas to find ways to provide treatment in tablet form and we are optimistic about starting a clinical trial within three years.”

Mater Researcher, Dr. Sherman Leung said laboratory tests in human stem cell models have shown that sRAGE inhibits specific T-cells in key areas of the body essential for the development of type 1 diabetes.

“We found strengthening the T-cell system by using sRAGE in the pancreas, pancreatic lymph nodes and splints to prevent diabetes, and resulted in better insulin expression and function,” says Dr. Leung.

“Our research suggests that sRAGE can be used to treat patients who have already had type 1 diabetes to help with improved blood glucose control because it can stop diabetes. inflammatory response which causes symptoms. “

The study was repeated by an independent research group at Novo Nordisk in the United States

According to the Australian Institute of Health and Welfare, type 1 diabetes affects about 12 out of every 100,000 Australians, with an average of almost seven new cases a day. The onset of type 1 diabetes occurs unexpectedly, often since childhood and is unrelated to lifestyle factors. People with type 1 diabetes are at increased risk of early death from complications including heart attack.

The study was published in the journal Diabetes Association of America Diabetes.


sRAGE is associated with an increased risk of developing diabetic nephropathy


Learn more:
Sherman S. Leung et al, Soluble RAGE Prevents Type 1 Diabetes Expansion of T cells, Diabetes (2022). DOI: 10.2337 / db22-0177

hintDiscovering essential protein boosts hope for type 1 diabetes (2022, July 14) restored 14 July 2022 from https://medicalxpress.com/news/2022-07-discovery-crucial-protein-boosts- diabetes.html

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