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Diabetes drug may help to prolong preterm pregnancies in women with pre-eclampsia

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Metformin, a drug given to women diagnosed with preterm preeclampsia, may help prolong pregnancy. BMJ today.

The findings show that the treated group had a week longer pregnancy compared to the untreated group, but the results were not statistically significant, indicating the need for further study.

If confirmed in future studies, this could bring significant benefits to both mothers and babies.

Pre-eclampsia is a serious condition that may be caused by an underdeveloped placenta.Premature birth Pre-eclampsia It often leads to preterm birth (between 26 and 32 weeks of gestation), putting the baby at risk of serious disability and death. Middle income country..

Metformin is usually given to diabetics to help control blood sugar levels, but preliminary studies suggest that it can also be a potential treatment for pre-eclampsia.

Therefore, researchers in Australia and South Africa have begun to assess whether sustained release metformin can be used to prolong pregnancy in women diagnosed with preterm preeclampsia.

The trial took place at a large hospital in Cape Town, South Africa, and was attended by 180 people. Pregnant woman I am undergoing close monitoring (watchful waiting) for preeclampsia of preterm birth.

Women were hired between February 2018 and March 2020, who were on average 29 weeks pregnant. None of them had diabetes or were currently using metformin or any other drug that might interact with it.

Women were randomly divided into two groups (arms): 90 received sustained release metformin and 90 received placebo daily until delivery.

The mean time from randomization to delivery was 17.7 days in the metformin group and 10.1 days in the placebo group, with a mean difference of 7.6 days. However, this difference was not statistically significant.

Two more analyzes were performed. The first (women who continued to take any dose of metformin) showed an average of 9.6 days longer pregnancies, and the second (women who took the full dose of metformin) showed an average of 11.5 days longer pregnancies. rice field. Both of these results were statistically significant.

There was no difference between the two arms regarding serious childbirth complications or death between both the mother and the baby. Diarrhea was more common in the metformin group, but no serious adverse events were observed.

Although this is a robust and well-designed test, researchers acknowledge some limitations. For example, the results may not be more widely applicable because this was a single-center study in which women had a higher incidence of HIV, obesity, and chronic hypertension.

Further trials of metformin should be considered to see if the drug can prolong pregnancy statistically significantly and to assess benefits to newborns, they say. However, based on the results of this study, “We are cautiously optimistic about sustained release. Metformin Extend pregnancy with woman With preterm preeclampsia. ”


Well-known drugs have less risk of preterm birth with PCOS


For more information:
Use of metformin to prolong pregnancy with preterm preeclampsia: randomized, double-blind, placebo-controlled trial, BMJ (2021). DOI: 10.1136 / bmj.n2103 , www.bmj.com/content/374/bmj.n2103

Quote: Diabetes drug is preeclampsia obtained on September 22, 2021 from https://medicalxpress.com/news/2021-09-diabetes-drug-prolong-preterm-pregnancies (September 22, 2021) May help prolong preterm birth in women with diabetes. html

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