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Delayed second-dose may have led to Delta variant’s dominance, says UK health agency-Health News , Firstpost

According to the UK Public Health Service, people who receive two doses of Pfizer vaccine have about 88% protection against delta variants, and one dose of Pfizer vaccine or AstraZeneca vaccine has 33.5% protection. Will be lower.

Cambridge: delta Coronavirus The first variant detected in India is currently the predominant variant in the United Kingdom.

Some experts warn that the delta variant may be 100% more infectious than the previous predominant variant, alpha. But I don’t think transmissibility alone can explain Delta’s dominance.

Successful mutants have biological benefits due to mutations and help them spread more easily between populations. And it is the mutants with these mutations that natural selection acts on, reliably defeating other less contagious strains.

However, delta variants can have more complex relationships with people than earlier variants. It may even have been government policy, not variant-specific increased transmission rates, that led to success and control in the UK.

To explain why, it helps to distinguish between some powerful forces that drive evolutionary change.

Initial natural selection occurs when one organism competes with another within or between species, leading to success in one and extinction in the other over time.

For example, one cheetah may be slightly faster than another cheetah, overtaking rivals, thereby catching prey, surviving, and breeding. Slow cheetahs are out of luck. It may not be able to find enough food to survive or attract companions, both of which will hinder its successful breeding.

The second force, artificial selection, is a subset of natural selection. It includes those who deliberately choose which organisms survive and proliferate.

An example of this is a horse breeder. For example, a horse with the desired quality of speed and obedience is allowed to mate with other horses by breeders, and the next generation of horses are more likely to have the same quality.

The third, lesser-known force, called the unconscious choice, is where human interaction with the environment influences accidental evolution. This further subset of natural selection is an important force around the world and is becoming more and more important as the population grows and people change the global environment.

Antibiotic resistance, in which bacteria evolve defenses against modern drugs, is a good example. As we continue to prescribe antibiotics to kill the bacteria, we unknowingly choose bacteria that are resistant to our treatment.

Another example is how agricultural practices relate to how the disease spreads among plants. The way people organize trees may help the disease spread more effectively.Some researchers said the 2009 swine flu outbreak, and probably COVID-19 (New Coronavirus Infection) The pandemic occurred for similar reasons.

The way we bring tree plants too close to each other in the world or delay vaccination is said to choose change in our world. And many of these changes, such as antibiotic-resistant super bugs and horrifying new variants, can hurt us.

The power to drive the delta

Returning to the delta variant, its ability to infect partially vaccinated people against it may explain its increased predominance.

According to the UK Public Health Service, a person who receives two doses of Pfizer vaccine has a protective effect of about 88%, but a single dose of Pfizer vaccine or AstraZeneca vaccine reduces this figure to 33.5%.

From the perspective of evolutionary choice, the UK Government’s decision to extend the period between the first and second vaccinations appears to have provided Delta with an additional window for infecting people.

Delta is likely to have evolved in India through natural selection, but unconscious selection may have ensured survival in the United Kingdom.

Other factors may have contributed to the success, such as the crowded living conditions and its high transmission rate in Bolton, a town in northwest England where the delta variant was first popular.

And the government’s decision, even if it contributed to the control of the variety, may not have been wrong. Hospitalizations and deaths appear to be low, even with a dramatic increase in cases.

However, it is important to think about the meaning of the artificial selection hypothesis if it is true.

Rather than making a full claim about the overall infectivity of the different variants, the different variants selected naturally or unknowingly, especially because different parts of the world are vaccinated at different rates. It becomes more and more important to think about how to do this. As they spread, they interact with new populations.

For example, the United States is focusing on offering two doses in a shorter time frame. And because of the success of the Delta variant in the United Kingdom, assuming the same problem in the United States is not necessarily justified. Choices can have different impacts on the two populations.

In a broader sense, this evolutionary perspective suggests that choices need to be looked at in order to make better predictions about which variant functions may lead to success in different populations. I will. Integrating evolution and artificial health sciences may be essential now and in the future to improve response to disease.

Delayed second-dose may have led to Delta variant’s dominance, says UK health agency-Health News , Firstpost Source link Delayed second-dose may have led to Delta variant’s dominance, says UK health agency-Health News , Firstpost

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