The COVID-19 vaccine reduces the number of serious COVID-19 infections in everyone regardless of body size, according to a new study published in Diabetes of Lancet & Endocrinology. The effect of the vaccine was similar for those with a higher BMI and of good weight, but less so in the low-weight group, who were also less likely to be vaccinated.
In a further study of people who were vaccinated only, in the recorded COVID-19 deficiency, people with lower and higher BMI were more likely to develop a serious infection than those who were vaccinated. This repeats the results of the findings seen in previous studies before starting the prevention program.
Obesity has been shown to be a risk factor for severe COVID-19 early onset of the disease, which has been demonstrated in the UK prevention Issue in 2021, which gives priority to people with a BMI over 40 as a risk group. However, little is known so far about the efficacy of COVID-19 in people with kiba. Previous studies have shown that obese people are less likely to take flu shots from time to time and have reduced the benefits of flu shots, although the reasons for this are not well understood.
“Our research provides further evidence that the COVID-19 injection saves lives for people of all ages. Our results provide assurance to obese people that the COVID-19 injection is just as effective for them as in people with low BMI, and high immunization rates. reduces the risk of serious infection if they are infected with COVID-19. These data also indicate the need for concerted efforts to increase immunization rates in people with low BMI , where the disease is currently lower than that of people with high BMI, ”he said. author Dr. Carmen Piernas of the Department of Primary Health Care at Nuffield, Oxford University, UK.
Researchers analyzed unnamed health data from more than 12 million patients in 1,738 GP services in the UK participating in QResearch – the most reliable health data available to verified researchers. Of these, 9,171,524 patients over the age of 18, had BMI data, and were never infected with SARS-CoV-2 in the study.
People were classified according to BMI according to the four World Health Organization definitions of 18.5-24.9kg / m2 for healthy weight; less than 18.5 for low weight; 25-29.9 for obesity; and 30 and above as obesity with adaptive measures for Asians to indicate a higher health risk at lower BMI levels in this group. Factors such as age, sex, smoking status, and social status were also included in the study.
Of the more than 9 million people included in the study, 566,461 tested for SARS-CoV-2 during the study from 8 December 2020 (the first immunization date in the UK) to 17 November 2021. Among of these, 32,808 were entered. hospital and 14,389 died.
At the end of the study period, 23.3% of the healthy group (817,741 of 3,509,231 people), 32.6% of the obese group (104,488 of 320,737 people), 16.8% of the obese group (513,570 of 3,509,231%) and 9. of the group of owners obese (322,890 of 2,278,649 people) do not have the COVID-19 vaccine.
To understand the effect of the vaccine, the researchers compared the risk of severe infection in the vaccine with those who had not been vaccinated at least 14 days after the second dose. They found that vaccination provided strong protection in all BMI groups, but the effect was slightly reduced in the less obese. People who have been vaccinated are less likely to be hospitalized or die compared to people who have not been vaccinated with the same BMI.
In comparison, people in healthy and high BMI groups who were vaccinated were almost 70% less likely to be hospitalized than people who were not vaccinated. People with a healthy BMI or higher have about two-thirds less likely to die than their unvaccinated counterparts two weeks after the second dose.
By looking at data from people who had only been vaccinated (in those whose COVID-19 levels were significantly reduced), the researchers found that following two doses of the vaccine there was a higher risk of serious infection at the bottom and at high BMI compared to healthy BMI. For example, a BMI of 17 was associated with a 50% increase in hospital risk compared to a healthy BMI of 23, and a BMI of 44 had a triple clinical risk compared to a healthy BMI.
It is not known what causes the increased risk among obese people. It corresponds to the highest number of seasonal flu cases in people with higher BMI. The authors speculate that their findings may, in part, be altered by altering the immune response in obese people. Decreased COVID-19 immunosuppression among people with low BMI may indicate a reduced immune response as a result of injury or other conditions related to body weight. Further research is needed to investigate the relationship between BMI and immune responses.
The authors agree to several limitations to the study, in particular, that certain BMI measurements are based on self-report, or on data recorded in GP data prior to the start of the study which may be default. Furthermore, the limited number of people who received three doses by close proximity means that the effects of the jabs could not be investigated, and the data did not allow researchers to search between Pfizer, AstraZeneca or Moderna vaccines , or bacterial variants. .
Writing in the related commentary, Professor Annelies Wilder-Smith and Professor Annika Frahsa of the Center for Public Health and Drug Prevention, University of Berne, Switzerland (who are not involved in the study) note , “There is a higher prevalence of immunization in people who suffer from it. On the contrary, obese people are less likely to be vaccinated, which may be the unintended consequence of public outcry. that obese people are at increased risk of serious COVID-19 infection through the UK-related strategies to increase immunization.take quick switch to more targeted and differentiated public health information to treat obese people who may be overweight at low risk to increase immunity in this category. ”
BMI groups with COVID-19 immunization, immunosuppressive effects, and the risk of serious COVID-19 side effects after immunization in the UK: a population-based study, Diabetes of Lancet & Endocrinology (2022). www.thelancet.com/journals/lan… (22) 00158-9 / fulltext
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