According to a new study, COVID-19 infection during pregnancy is not associated with stillbirth or premature neonatal death.
A study published in a journal led by scientists at Imperial College London Ultrasound in obstetrics and gynecologyUsage data from the United Kingdom and the United States.
The research team examined data from 4004 pregnant women who suspected or confirmed COVID-19. Of these women, 1606 were from the United Kingdom from a data registry called PAN-COVID, and 2398 were from the American Academy of Pediatrics’ SONPM data registry.
PAN-COVID was funded by the Medical Research Council, the National Institute for Health Research, and the NIHR Imperial Center for Biomedical Research.
All women gave birth between January and August 2020.
The study found that no infant died of COVID-19.There was no increased risk of stillbirth or stillbirth Low birth weight..
However, both UK and US data suggest an increased risk of preterm birth (defined as giving birth 37 weeks ago).
UK data show that 12% of women with suspected or confirmed COVID-19 were preterm. This is 60% higher than the national average of 7.5%. According to US data, 15.7% of women give birth prematurely, 57% higher than the US national average of 10%.
Part of this link, the researchers say, may be because doctors decided to give birth to the baby early because of concerns about the effects of COVID-19 infection on mothers and babies. The rate of spontaneous preterm birth was lower than expected.
Professor Christoph Lees, senior author of research in the Department of Metabolism, Digestion and Regeneration of Imperial, said: “The discovery that COVID-19 infection does not increase the risk of stillbirth or infant mortality is encouraging. 19 Diagnosis is associated with an increased risk of preterm birth, for which the reason is not entirely clear.”
Dr. Ed Malins, co-author of the Department of Metabolism, Digestion and Regeneration of Imperial, said: “This study supports prioritization of vaccination for pregnant or prospective women and existing measures to protect pregnant women from infection. To reduce preterm birth.”
The proportion of infants born to mothers with confirmed COVID-19 and subsequently positive for the SARS-CoV-2 virus (the cause of COVID-19) was 2% in the UK study and 1.8% in the US study. ..
The majority of women in this study did not have pre-existing conditions such as diabetes or respiratory conditions such as asthma.
A UK study killed eight women and a US study killed four women.
According to the research team, these mortality rates are higher than expected for women giving birth, but similar to those expected for adults with confirmed COVID-19 infection. This suggests that pregnant women are not at higher risk of death from COVID-19 than non-pregnant women.
Of the women in the UK sector surveyed, 66.5% are Europeans or North Americans, 1.9% are Middle Eastern, 1.1% are North Africans, 4.2% are Africans in the Sahara or Southern Caribbean, and 7.5% are Indian subcontinents. I was from. 9.2 percent were Southeast Asians. In the US sector of the survey, 37% were white, 25% were black or African, 4.1% were Asian, and 0.4% were Native or Alaska Natives.
Professor Fiona Watt, Executive Chair of the Medical Research Council, who helped fund the research, said: “It’s clearly important to understand how COVID-19 affects different groups of people. We’re proud to have funded this study. Last year, researchers were quite a bit. We monitored the health of a number of pregnant women and their babies. The findings that women infected with COVID-19 during pregnancy still do not increase the risk of childbirth or premature death of newborns are reassuring, this study found. It emphasizes the need for further research to determine if or how COVID-19 affects maternal outcomes. Premature birth... “
The SONPM Data Registry of the American Academy of Pediatrics was led by Professor Mark Hudak.
The Center for Testing and Research at Cardiff University was responsible for building online databases, managing data, and performing statistical analysis. Julia Townson, Senior Research Fellow and Co-author at Cardiff University, said: “We are pleased that the Cardiff University Trial and Research Center was able to collaborate with Imperial College London on this important study, which requires the team to quickly build databases and web pages, and clean and analyze the data. is.”
Imperial College London
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