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Commercial T cell test reveals factors correlated with diminished responses to SARS-CoV-2 in clinical study subjects

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T cell testing using the commercial T virus test, QuantiFERON SARS-CoV-2 RUO, sheds light on the immune response to infection and vaccination patients with COVID-19 and suggests that age and time from infection are important factors related to the size of the cell-mediated immune response (CMI) to COVID-19. The study was presented at ASM Microbe 2022, the annual meeting of the American Society for Microbiology.

The outcome of the new study is based on evidence from the clinical research study it contains human issues It was held from June 2021 to February 2022 in the United States and the Netherlands. Cells of the SARS-CoV-2 T cell can provide researchers and clinicians with information about a person’s ability to fight future COVID-19 infections. QuantiFERON SARS-CoV-2 RUO, a commercially available T virus test, detected T cell-mediated immune response in 80% of clinical trials subjects who completed COVID-19 vaccination in the past 24 weeks (6 months) ).

When evaluating factors that may include T cell responses observed after vaccination, simply increase the age associated with T cell response. Time from vaccine, type of vaccine received, or sex is not related to the response of T. genes In cases of SARS-CoV-2 infection, QuantiFERON SARS-CoV-2 RUO detected T virus responses in 74% of cases in the last 24 weeks. The only thing that is related to the lack of T virus response after infection is the time elapsed after infection.

“This study strengthens current knowledge by linking age and time from infection with reduced immunity to SARS-CoV-2, which in turn may contribute to a faster onset of infection and subsequent infections,” he said. heard Robin Uchiyama, Director of Clinical Studies, Clinical Affairs. at QIAGEN and lead author on the study. “This work highlights the importance of T virus testing and the implementation of stricter prevention measures, such as vaccines, enhancers and masks, even after vaccination. great wine or after infection. ”

QIAGEN Clinical Affairs is leading the QIAGEN project in Germantown, Md. and will be presented at the ASM Microbe in Washington, DC on Saturday, June 11, 2022.


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hintCommercial T cell test reveals factors related to the reduced response to SARS-CoV-2 in clinical research topics (2022, June 11) retrieved June 11, 2022 from https://medicalxpress.com/news / 2022-06-commercial-cell-express-items-reduction.html

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Commercial T cell test reveals factors correlated with diminished responses to SARS-CoV-2 in clinical study subjects Source link Commercial T cell test reveals factors correlated with diminished responses to SARS-CoV-2 in clinical study subjects

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