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Cold temps may help to combat obesity and related metabolic diseases by reducing inflammation, researchers find

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More than 40 percent of U.S. adults are obese, a complex condition that can increase the risk of diabetes, heart disease and other cancers. One of the ways that obesity can lead to other health problems is by causing low-grade inflammation, accumulating antibodies in insulin secretions. Scientists predict that reversal – also known as reversal – this chronic inflammation may prevent the onset of obesity-related diseases including diabetes and possibly facilitate weight loss.

In a new paper published in Nature Metabolism, Researchers at the Joslin, Brigham and Diabetes Center and Women’s Hospital found that cold weather solved the problem of obesity while improving insulin secretion and glucose tolerance in rats that cause food poisoning. The team further explained that the system is based on a type of brown adipose (oil) — sometimes considered “good” – produces a natural molecule called Maresin 2 when the cold moves. he. It is known as an active endocrine gland because it hides viruses that communicate with other tissues and regulate metabolism, brown adipose tissue it helps to dissipate stored energy and can increase efficiency weight loss healthy metabolism.

“Evidence suggests that obesity and lifestyle problems are closely linked chronic inflammation which causes insulin resistance, so stopping inflammation in obesity may provide a better treatment for obesity-related diseases, ”said co-author Yu-Hua Tseng, Ph.D., senior researcher in the Department of Molecular Biology and Metabolism at the Joslin Diabetes Center and professor of medicine at Harvard Medical School at least in part by activating brown adipose tissue. These findings suggest an unknown function of brown adipose tissue to improve inflammation resolution in obesity. “

In two previous studies, Tseng and colleagues found that the appearance of cold can activate brown fat to produce specific lipid mediators that regulate food metabolism. In the current study, the researchers found a new position for lipid mediators produced from brown matter to treat inflammation.

In the current study, scientists have created a mouse model that becomes fatter when fed regular fatty foods. When the animals were exposed to cold weather (approximately 40 Fahrenheit), the researchers noticed that the animals’ insulin sensitivity and glucose metabolism improve them body weight is reduced, compared to the control of animals kept in an area of ​​thermoneutral-temperature environment where the body does not need to produce heat to maintain its actual temperature. What’s more, scientists have also noticed a big improvement in inflammation, as measured by reducing the levels of a major symptom of inflammation.

“We’ve found that brown fat produces Maresin 2, which treats inflammation in the gut and in the liver,” said lead author Matthew Spite, Ph.D., senior researcher at Brigham and Women’s Hospital and Assistant Professor of Anesthesia at Harvard Medical School. . “These findings suggest an unfamiliar function of brown adipose tissue to improve inflammation resolution in obesity by producing this essential lipid intermediate.”

In addition, these studies also suggest that Maresin 2 may have clinical application as a treatment for patients with kiba, chronic diseases, or other diseases associated with chronic inflammation; however, the virus itself breaks down rapidly in the body. Tseng and colleagues are looking for improved analog of chemicals for clinical use.

The group noted a short-term approach to improving quality of life is likely to exist. Deal human studies held in Joslin and other places to express dissatisfaction cold weather (50 to 55 degrees Fahrenheit) has been shown to be sufficient to activate brown adipose tissue and improve metabolism, although the mechanisms are not well understood.


‘Energy crisis’ in fat cells behind obesity-related inflammation


Learn more:
Satoru Sugimoto et al, Brown adipose tissue-derived MaR2 contributes to the cold resolution of inflammation, Nature Metabolism (2022). DOI: 10.1038 / s42255-022-00590-0

hintCold weather can help treat obesity and related diseases by reducing inflammation, researchers found (2022, June 27) restored 27 June 2022 from https://medicalxpress.com/news/2022-06- cold-temps-combat-obesity -metabolism.html

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Cold temps may help to combat obesity and related metabolic diseases by reducing inflammation, researchers find Source link Cold temps may help to combat obesity and related metabolic diseases by reducing inflammation, researchers find

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