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CircRNA rtcisE2F regulates self-renewal of liver tumor-initiating cell by crosstalking with RNA m6A modification

6The E2F6 / E2F3 mRNAs have m6In IGF2BP2 / YTHDF2 readers, and ultimately enhances the stability of E2F6 / E2F3 mRNAs. E2F6 and E2F3 exert Wnt / cat-catenin signal activation and self-regulation of liver TICs. Credit: Science China Press “width =” 800 “height =” 516 “/>

rt-circRNA rtcisE2F is derived from two molecules CYP2C18 and CYP2C19, including a link between m6The E2F6 / E2F3 mRNA and m6Readers IGF2BP2 / YTHDF2, and ultimately enhance the stability of E2F6 / E2F3 mRNAs. E2F6 and E2F3 exert Wnt / cat-catenin signal activation and self-regulation of liver TICs. Credit: Science China Press

Liver cancer is one of the leading causes of cancer in China. Tumor-induced tumors (TICs), small tumors in the tumor with self-reported and differentiated, play an important role in tumor formation, metastasis, drug resistance and recurrence. circRNAs, which are detected by the 5 da and 3 haɗin junctions ending in the posterior, play an important role in regulation in many physiological and pathological systems. However, the role of cirRNAs in liver cancer and TICs needs further study.

Recently, the Pingping Zhu (School of Life Sciences, University of Zhengzhou) and Benyu Liu (Committee of Public Health Sciences, Zhengzhou University) discovered a circrNA, called rtcisE2F, which is well described in liver TICs. rtcisE2F plays an important role in the self-regulation of liver TICs. rtcisE2F attacks E2F6 and E2F3 mRNAs, reduces mRNA conversion, and increases expression of E2F6 / E2F3. Engineering, rtcisE2F works as a simplest form6Reader IGF2BP2 and valid6Modified E2F6 / E2F3 mRNA. rtcisE2F enhances the binding of E2F6 / E2F3 mRNAs with IGF2BP2, and inhibits the interaction with other m6Reader, YTHDF2. IGF2BP2 inhibits the degradation of E2F6 / E2F3 mRNA, while YTHDF2 inhibits the degradation of E2F6 / E2F3 mRNA. By changing the approach6Reader, rtcisE2F enhances the stability of E2F6 / E2F3 mRNA. Both E2F6 and E2F3 require liver TIC self-renewal and Wnt / β-catenin activation, and inhibiting these mechanisms is a potential mechanism to prevent liver tumorigenesis and metastasis.

Although some research has been done on potential projects6Changes in circRNAs in tumorigenesis and tumor metastasis, there have been few reports on interactions between m.6Modification of circRNA, as well as studies on interactions between m6CircRNA in liver cancer and TICs are still lacking. New research by Pingping Zhu and Benyu Liu shows that circRNA plays an important role in binding6MRNA is modified to different molecules6The readers. The rtcisE2F -IGF2BP2 / YTHDF2-E2F6 / E2F3-Wnt / cat-catenin pathway has been identified for the first time to drive the self-regulation of liver TICs, in addition to HCC metastasis as well. Moreover, these findings may provide additional strategies for eliminating liver TICs.

The project is published in Chinese Life Sciences.


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Learn more:
Zhenzhen Chen et al, rtcisE2F promotes autoimmune and metastasis of hepatocellular carcinoma by N6-methyladenosine-dependent E2F3 / E2F6 mRNA stability, Chinese Life Sciences (2022). DOI: 10.1007 / s11427-021-2038-5

Its formation
Chinese Journalism

hintCircRNA rtcisE2F regulates the self-regulation of the hepatocellular carcinoma by communicating with RNA m6A repair (2022, April 8) retrieved 8 April 2022 from https://medicalxpress.com/news/2022-04-circrna- rtcise2f-self- update-hanta-tumor-initiating.html

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CircRNA rtcisE2F regulates self-renewal of liver tumor-initiating cell by crosstalking with RNA m6A modification Source link CircRNA rtcisE2F regulates self-renewal of liver tumor-initiating cell by crosstalking with RNA m6A modification

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