Choline makes a key nutrient available for baby development

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Choline protein – which has been shown to have long-term benefits for infants consumed by their mothers during pregnancy – also helps the body to use omega 3 fatty acids which are important for the fetal brain, understanding and vision development, new research finds.

The study was published on May 16 in American Journal of Nutrition.

The results of the study show that choline supplements support cellular metabolism to control the quality and release of omega 3 fatty acid DHA from a abdomen human liver. Once released into the bloodstream, DHA can be delivered to all tissues, including the uterus.

“During pregnancy, the mother begins to get nutrients from the liver and supplies them to the baby, thus increasing choline and DHA. [together]we are increasing DHA bioavailability, “said lead author Marie Caudill, professor of nutrition at Cornell College of Agriculture and Life Sciences. Kevin Klatt, Ph.D., a research scientist and registered nutritionist at Jami California, Berkeley, is the newspaper’s first author.

These kinds of nutritional interactions are not new, Caudill said. For example, there is a well-known combination in the intestine where vitamin D enhances the absorption of calcium and vitamin C increases iron absorption.

Caudill and others at Cornell have also shown that a mother’s high choline intake facilitates the baby’s response to stress, improves data processing and has long-term benefits in long-term care (as shown in the previous study identifying children up to 7 years), and pregnancy. in women, choline reduces what contributes to preeclampsia.

In this study, a group of 30 women at 12 to 16 weeks were randomly divided into two groups: one was given 500 milligrams of choline per day, and 50 milligrams per day of choline labeled deuterium, for so it can be followed physically. The other group worked as a control and were given 25 milligrams per day of only choline. All DHA participants were also given a supplement of 200 milligrams per day, extra vitamins and minerals, and were able to eat their daily diet. Blood and urine were taken after fasting at the beginning of the test for baseline, then during pregnancy weeks 20-24 and 28-30 weeks. Uterine blood and umbilical cord blood were also taken at birth.

By tracking choline markers, the researchers identified a type of chemical that choline contributes to small molecules called methyl groups that are added to a cell called phosphatidylethanolamine. Biologically, phosphatidylethanolamine is converted to a new molecule containing choline, phosphatidylcholine, enriched with DHA. In this form, DHA is excreted from the liver into the mother’s bloodstream, where it is absorbed into the tissues.

Future work will help determine whether choline’s ability to increase the bioavailability of DHA contributes to some of the benefits experienced when pregnant women increase choline.

“Our results will show that extra choline can help achieve higher DHA levels with lower DHA during pregnancy,” Klatt said. “Our data indicate a desire to eat choline as an important determinant of the amount of DHA in the diet that puts it in the tissues in it.”

Collaborative authors include researchers from Baylor College of Science; University of California, Berkeley; University of Chiang Mai, Chiang Mai, Thailand; OmegaQuant Analytics in Sioux Falls, South Dakota; University of British Columbia in Vancouver; Cayuga Health Center in Ithaca; and University of Texas, Austin.

Intrauterine intake of choline during pregnancy affects the quality of care of the baby

Learn more:
Kevin C Klatt et al, Prenatal choline supplementation promotes biologists’ status of docosahexaenoic acid in pregnant women taking additional DHA: a controlled trial, American Journal of Nutrition (2022). DOI: 10.1093 / ajcn / nqac147

hintCholine provides a key ingredient for infant formula (2022, May 18) which was returned May 18, 2022 from

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