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Candidate biomarkers identified for psoriasis progression

Candidates biomarkers for the development of the disease have been identified in psoriasis, according to a review published online April 28 in British Journal of Dermatology.

Ravi Ramessur, BMBS, from King’s College London, and colleagues conducted a systematic review of relevant publications published between 1990 and December 2021 to identify potential candidate biomarkers. disease progression in psoriasis. Data were collected from 181 studies, most of which examined genetically or genetically related pathogens or psoriatic arthritis (145 and 30, respectively).

The researchers identified potential genomic, proteomic, and metabolomic biomarkers with potential future benefits for prognosis. severe diseaseincluding LCE3D, interleukin (IL) 23R, YESL23A, NFKBIL1 loci, da HLA-C * 06:02 (genomic); IL-17A, immunoglobulin G aHDL, GlycA, I-FABP, and Kallikrein 8 (proteomic); and tyramine (metabolism). Genomic (HLAC * 06: 02, HLA-B * 27, HLA-B * 38, HLA-B * 08and differences in Download: IL23R same to you Price IL13 loci), proteomic (IL-17A, CXCL10, Mac-2 binding proteins, Integrin b5, MMP-3, and M-CSF), and metabolomic (tyramine and mucic acid) biomarkers have also been identified for psoriatic arthritis. The difference in Price IL12B same to you Download: IL23R loci were genomic markers identified for type 2 diabetes mellitus in psoriasis.

“From the genetic diversity and results examined in the combined study, we identified two potential biomarkers (10 genomic, 10 proteomic, and two metabolomic) but note that none has enough evidence to use the clinic without further confirmation, ”the authors wrote.

Many authors describe the financial relationship with the pharmaceutical industry.


Blood levels of two markers can help assess the health of people with skin conditions related to the skin


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