Colorectal Cancer Raises the Risk of Death From Heart Disease

For people with colorectal cancer, life-threatening health problems can extend beyond the cancer itself. A new study finds that these individuals are 16 percent more likely to die of cardiovascular causes than people without colorectal cancer.

The research, to be presented at the American College of Cardiology’s Annual Scientific Session in Chicago, analyzed data from more than 630,000 patients.

“To our knowledge, this is the first population-based study assessing disparity in cardiovascular mortality in different groups among patients diagnosed with colorectal cancer,” says study author Ahsan Ayaz, MD, an internal medicine resident at Montefiore St. Luke’s Cornwall Hospital in Newburgh, New York.

Looking at such a large dataset allowed the researchers to find out which subgroups faced the highest risks, and how to mitigate those risks for the best survival outcomes, Dr. Ayaz says.

The First 2 Years After Diagnosis Are Critical

Ayaz and his team looked at medical information on people diagnosed with colorectal cancer between 2000 and 2021.

They included in their analysis anyone who died from complications of:

  • Heart disease
  • High blood pressure
  • Cerebrovascular diseases such as stroke
  • Atherosclerosis, or blocked arteries
  • Aortic aneurysm, a bulge in the main artery of the body

The research found that the chances of dying from heart problems were highest in the first two years after a colorectal cancer diagnosis. During this period, the risk was 45 percent greater.

While the study doesn’t directly address the reasons, this period coincides with intensive cancer treatment, including chemotherapy, radiation, and surgery — each of which can impact cardiovascular health, says Robert S. Copeland-Halperin, MD, an assistant professor of cardiology at the Zucker School of Medicine at Northwell Health in Uniondale, New York, and a member of the cardio-oncology council of the American College of Cardiology.

“Previous studies have also shown an initial spike in risk within the first year, with another increase beyond five years, likely reflecting long-term effects of treatment and survivorship-related factors,” says Dr. Copeland-Halperin, who was not involved in the research.

Identifying Groups at Highest Risk of Dying

For adults younger than 50, the odds of dying were especially pronounced. This population was 2.4 times more likely to die of heart-related causes than people in the same age group who did not have colorectal cancer.

At this point, researchers don’t know why this is the case. Ayaz calls it one of the “most curious” questions yet to be answered, although he does point out that the incidence of colorectal cancer has been increasing in younger adults.

It could be that this younger population faces a higher risk of death because early onset colorectal cancer is more aggressive, requiring more intensive treatment that impacts the heart, says Salim Hayek, MD, a cardiologist with the University of Texas Medical Branch at Galveston and the chair of the American Heart Association’s cardio-oncology committee.

“Possible genetic factors may also link early-onset colorectal cancer with cardiovascular vulnerability,” says Dr. Hayek, who was not involved in this research.

He adds that cancer treatments, particularly chemotherapies like 5-fluorouracil commonly used in colorectal cancer, can damage the cardiovascular system. These treatments may cause:

  • Vasospasm (when arteries constrict)
  • Ischemia (reduced blood flow to the heart)
  • Arrhythmias (irregular heartbeats)
  • Indirect effects such as new high blood pressure accelerated plaque buildup in the arteries

The study found that Black adults with colorectal cancer faced a 74 percent higher risk of death from heart complications.

This result corresponds with American Heart Association data showing that Black communities in the United States have disproportionately higher risk of heart disease, stroke, and high blood pressure.

Men with colorectal cancer had a 55 percent greater risk, which jibes with statistics showing that men generally are at greater risk of heart disease than women.

How to Lower Your Risk of Heart Problems After Colorectal Cancer Diagnosis

Because this two-year period is critical, Ayaz advises his patients to make a concerted effort to control heart disease risk factors during this time.

“Ask questions of your treating doctors about your personal risk factors for developing heart disease, especially when facing a cancer diagnosis, and ask about cardiovascular risks associated with the proposed treatment for your cancer,” says Helga Van Herle, MD, a cardiologist with Keck Medicine of USC in Pasadena, California, who was not involved in the study.

To reduce cardiovascular risk factors, she recommends:

  • Treating high cholesterol
  • Managing high blood pressure
  • Treating diabetes
  • Quitting smoking
  • Losing weight if necessary
  • Following a healthy diet
  • Getting exercise

“While patients diagnosed with cancer can’t change the past, we know that potentially treatable risk factors including lifestyle and conditions like high blood pressure, diabetes, and elevated cholesterol increase the risk for heart related complications,” says Copeland-Halperin. “So addressing these represents a significant potential opportunity to improve the outcomes.”

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What Is LADA Diabetes?

When first diagnosed with diabetes, people with LADA may not yet need insulin injections. At this stage, your treatment will concentrate on improving your blood sugar control, which may help preserve your natural ability to secrete insulin. To achieve this, your doctor may use type 2 diabetes drugs such as metformin or GLP-1 receptor agonists, which can help improve insulin sensitivity. Lifestyle adjustments, such as a wholesome diet and enhanced physical activity, could also extend this period before insulin treatment becomes necessary.

Eventually, however, everyone with LADA will need insulin. Some doctors may choose to prescribe insulin relatively soon after diagnosis, while others may prefer to wait until it is no longer possible to control blood sugar levels without it.

Initially you may be prescribed a long-acting “basal” insulin. This is a once or twice-daily injection that provides a constant steady stream of insulin. When you begin taking insulin, you may also need to increase the frequency with which you test your blood sugar, partially to help reduce the risk of low blood sugar (hypoglycemia). Some doctors will encourage you to use a continuous glucose monitor (CGM), a device that measures your blood sugar constantly around the clock and sends data to a smartphone app or a separate receiver.

Finally, you will probably need to start using a rapid-acting insulin before every meal you eat. At this stage in LADA’s progression, treatment is essentially identical to the treatment of type 1 diabetes. Intensive treatment is very complex and occasionally frustrating, and many people with LADA will rely heavily on their healthcare teams to help them navigate this new challenge.

No other medication is specifically approved to treat LADA.

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Ease IBS-C with These 6 Simple Food Swaps

Maybe you’ve noticed you can’t eat the same foods you used to. Or that your go-to drink prevents you from ever … well … going. When managing irritable bowel syndrome with constipation (IBS-C), it can be hard to know how to start building a diet that won’t trigger symptoms.

“What you eat and how you eat is so important when you have IBS-C,” says Katrina Cox, a registered dietitian specializing in IBS and gut health in Providence, Rhode Island.

Making a few easy, important swaps may make all the difference when it comes to keeping bloating, constipation, and stomach pain at bay.

IBS-Friendly Food Swaps to Ease Constipation

The good news is, you can keep your diet rich and varied with some smart food swaps. Because these foods support healthy digestion, they’ll help you stay more regular. Here are six to try:

1. Reach for Cooked Veggies Over Raw

It’s so easy (and refreshing!) to grab a handful of baby carrots or broccoli florets out of the fridge to dip into hummus. Plus, they provide fiber, which helps keep things moving.

 But, according to Cox, the body typically tolerates cooked veggies better than raw ones. This is because cooked vegetables require less effort to digest, so your body doesn’t have to work as hard when breaking them down. Even just steaming your vegetables makes digesting them easier for your body.

Good veggie choices for IBS-C are those that are low in FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols), which are a group of carbohydrates that the body can’t completely digest or absorb. Because IBS causes a sensitive gut, incorporating low-FODMAP foods is all the more important.

Low-FODMAP vegetables include carrots, cucumbers, green beans, green bell peppers, potatoes, and zucchini.

2. Swap Wheat Toast for Oatmeal

If you’re typically doing toast for breakfast, switch to oatmeal. Wheat bread contains oligosaccharides, a FODMAP associated with IBS symptoms.

 Oatmeal, on the other hand, is a good source of soluble fiber that soaks up water to bulk up your stool, making it easier to pass.

3. Take Your Coffee Hot Instead of Iced

A steaming cup of joe can help you stay regular. Coffee contains chlorogenic acid, which stimulates digestion, and caffeine, which stimulates movement in the colon.

One tip: Consider taking your coffee with almond milk, rather than cow’s milk, which is higher in disaccharides (a FODMAP) in the form of lactose. Or you can switch to lactose-free milk.

4. Skip Onions and Garlic and Try Scallion Tops and Chives

Garlic and onions are two of the foods that make so many meals taste great, but they’re both high in FODMAPs and common culprits behind IBS symptoms.

 If you’re still chasing that oniony taste, Cox recommends using scallion tops (the green part of green onions) or chives.

Another clever tip? Use garlic- or onion-infused oil to cook. All you get is the flavor in the oil, not the FODMAP, she says. You can buy these oils at specialty markets or create your own by sautéing garlic or onion in oil and then removing (and discarding) the solids from the oil.

5. Switch Out (Some) Meat for Plant-Based Proteins

There’s no reason to exclude animal protein from your diet if you have IBS-C, but you may want to replace at least some of it with plant proteins, such as tofu and tempeh.

Because they’re fermented, these soy products are a rich source of probiotics that can help populate your gut with digestion-friendly bacteria, which can ultimately give your immune system a boost, too.

If you aren’t a fan of plant-based proteins, opt for other fermented foods, such as kefir, kimchi, kombucha, or sauerkraut.

6. Opt for Chia Seeds and Flaxseeds Over Pistachios

Pistachios and cashews are high in FODMAPs.

Instead, Cox recommends trying the fiber-packed seeds of chia and flax plants. A half ounce of chia seeds offers about 5 grams of fiber,

while a half ounce of ground flaxseed has about 4 grams of fiber.

 She suggests adding them to a yogurt parfait or overnight oats.

When looking to ease constipation, adding more fiber to your diet, along with plenty of water, is the way to go. But keep in mind that fiber adds to IBS-C symptoms for some people. With a little practice, you’ll learn which foods satisfy your taste buds, fill you up, and don’t trigger IBS symptoms for you.

The Takeaway

  • Managing irritable bowel syndrome with constipation involves making simple but effective changes to your diet to prevent symptoms such as bloating and discomfort.
  • Pick cooked vegetables over raw ones, and add some coffee and fiber-rich chia seeds or flaxseeds to your diet to keep bowel movements regular.
  • Swap high-FODMAP onions and garlic for lower-FODMAP scallion tops and chives or garlic- or onion-infused oil to reduce your exposure to these common IBS triggers.

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Connection, Treatment, and When to Seek Help

Many people with psoriasis also experience varying levels of psychological distress from the condition.

Researchers compiled data from systematic reviews, meta-analyses, and randomized control trials on depression, suicidality, anxiety, and psoriasis. According to their review of the findings, people with psoriasis are 1.5 times more likely to have depressive symptoms than those without.

While social factors like self-esteem issues or embarrassment over how psoriasis physically looks can worsen mental health issues, research suggests other factors can contribute to depression as well.

Inflammation

As in the case with many autoimmune diseases, one of the primary causes of psoriasis is inflammation. With psoriasis, the lack of regulation within the immune system that leads to inflammation can also play a role in the development of depression.

“There is growing evidence that chronic inflammation in psoriasis contributes to an inflammatory response in the brain and spinal cord (neuroinflammation), which plays a role in depression,” says Dr. Khan.

The psychiatrist says this is caused by small, pro-inflammatory proteins called cytokines. Within the cells, these proteins affect immune responses, and have been linked to changes in brain chemistry that can contribute to mood disorders. These cytokines impact brain communication in a way that’s aligned with inflammation.

“This is one reason why individuals with psoriasis and other inflammatory conditions may have higher rates of depression and anxiety,” Khan says.

Physical Discomfort

Psoriasis plaques (rashes) can vary in appearance depending on your skin tone, and are dry and scaly. These areas can also be uncomfortable, potentially causing burning, stinging, or itching.

For some people with psoriasis, this itching and discomfort can also affect sleep. Lack of sleep can worsen overall health, and poor sleep habits can also leave you more vulnerable to depression.

Reduced Self-Esteem and Isolation

A skin condition like psoriasis can lead to social withdrawal, Khan says. This is particularly true when affected areas are highly visible.

Hannah Kopelman, DO, a dermatologist with Kopelman Aesthetic Surgery and Kopelman Hair Restoration in New York City, says this is often the case with psoriasis, which commonly affects the scalp, elbows, arms, and knees.

People with psoriasis may also feel emotional discomfort and shame related to the condition.

Some with psoriasis feel concern about how the public or loved ones will react to their skin’s appearance. “One of the most common things with psoriasis is that people don’t want to leave their house because they’re depressed by their skin manifestations,” Dr. Kopelman says.

This impact on self-esteem can lead to social avoidance. “The social withdrawal, avoidance of intimate relationships, and anxiety about public perception can lead to feelings of loneliness, which is a significant risk factor for depression,” Khan says.

“Low self-esteem is common in individuals with psoriasis, particularly if they have experienced bullying, comments about their appearance, or rejection due to their condition,” he says.

Co-occurring Conditions

Psoriatic arthritis often acompanies psoriasis, and chronic pain can contribute to depression.

Because psoriatic arthritis has the potential to affect mobility, this can further contribute to social isolation and make someone less likely to engage in things that them bring joy, Kopelman says.

In addition to psoriatic arthritis, psoriasis comes with a higher risk for:

Navigating additional health concerns alongside a visible skin condition can prove overwhelming. This can ultimately lead to worsening depression.

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2025 Allergy Season: How to Reduce Symptoms

With spring just starting, tens of millions of Americans with allergies are bracing for the return of sneezing, congestion, itching, and watery eyes as pollen fills the air.

This year, the spread of pollen is expected to be more intense and longer lasting than in the past, starting earlier in the spring and ending later in the fall.

“Unfortunately, every year pollen counts seem to be getting worse, and that’s largely related to global warming,” says Payel Gupta, MD, an allergist with Tono Health in Brooklyn, New York, and a medical spokesperson for the American Lung Association.

Warmer seasonal air temperatures and more carbon dioxide (CO2) in the atmosphere spur plant growth. This in turn leads to more pollen, a powdery substance created by certain plants as part of their reproduction process.

The Winter Allergy Break Is Getting Shorter

Pollen seasons come in three distinct waves:

  • Tree pollen, generally lasting from February through April
  • Grass pollen, from April through early July
  • Weed pollen, from August to the first hard frost

“Because spring allergies can start as early as February, and weed pollen allergies can last as late as November, we’re really not having much respite from allergies,” says Dr. Gupta.

“Some people can definitely be ‘poly-sensitized’ or allergic to many different environmental allergens, so they may now only get a small break from allergies in the winter, and that break is getting shorter and shorter,” Gupta adds.

Allergy Predictions for 2025

In its allergy forecast for 2025 released last week, Accuweather notes that tree pollen is on the rise in southern U.S. states, but a cold start to the year in the eastern part of the country may keep tree pollen levels low in that region until later in the spring.

The worst tree pollen is anticipated in part of the Gulf Coast, across the central Plains, and into the northern Rockies and Pacific Northwest.

“Every region in the country is going to have its own unique, challenging pollen, but there are plants everywhere, and those pollens can travel hundreds of miles, so there’s really no safe place to be when it comes to seasonal allergies,” says Christopher Codispoti, MD, an associate professor of allergy and immunology at UTHealth Houston in Texas.

Worst Cities for People With Allergies

Every year, the Allergy & Asthma Foundation of America (AAFA) lists the U.S. cities that are hardest hit with seasonal allergies. Its top 10 allergy capitals for 2025 are:

  1. Wichita, Kansas
  2. New Orleans, Louisiana
  3. Oklahoma City, Oklahoma
  4. Tulsa, Oklahoma
  5. Memphis, Tennessee
  6. Little Rock, Arkansas
  7. Raleigh, North Carolina
  8. Richmond, Virginia
  9. Greenville, South Carolina
  10. Greensboro, North Carolina

How to Tell Allergies From a Cold

One of the difficulties with a seasonal allergy is how to tell it apart from a common cold because many of the symptoms overlap. Per Mayo Clinic, both can cause:

  • Runny nose
  • Congestion
  • Fatigue
  • Sneezing

“Sneezing will occur with cold and flu, but with allergies you have more of a nasal itch, and the sneezing is often more frequent and intense,” says Dr. Codispoti.

He adds that itchy, puffy eyes are common with allergies but rare with a cold.

Mayo Clinic further notes that allergies rarely cause a sore throat, cough, or fever, while those can be signs of a cold, flu, or other respiratory virus.

Tips to Help Manage Allergy Symptoms

No matter what effects you feel from allergies, many options are available to keep symptoms at bay:

Start your allergy medications as soon as possible. Antihistamines and nasal sprays, whether they’re prescription or over-the-counter, need time to build up in your system, so it’s best to start taking them two to four weeks before allergy season begins.

Discuss medication options with a healthcare provider. Many medication choices are available to treat allergy symptoms, but it can take expertise to find the right match for you. If antihistamines aren’t helping, an allergist may advise trying a nasal spray, for example.

“I find that a big part of my job is making sure that people understand how to use medications appropriately,” says Gupta. “If you’re trying different medications on your own and they’re not working, it might be time to see an allergist.”

Keep windows closed, if possible. Pollen can come through an open window and get into bedding and furniture, worsening symptoms. If you have to open windows at times, an air purifier or air conditioner with a HEPA (high-efficiency particulate air) filter can reduce airborne allergens.

Consider wearing a mask outdoors. If the pollen count is very high, a mask can help block allergens. Gupta says masking can be especially helpful when mowing the lawn or doing other yard work.

Take off shoes and wash clothes. Pollen can enter a home on shoes and clothes. After being outside, leave shoes at the door, and change and wash garments after outdoor activities.

Be cautious with pet contact. Dogs and cats that spend time outdoors can get pollen on their fur, so close contact may worsen symptoms. Bathe your pet regularly and wipe them off when they come inside to limit pollen exposure. Also, keep pets out of the bedroom.

Take a shower at night and wash your face. Before going to sleep, shower to remove pollen from your body so you’re not tracking it to your bed where you could be inhaling it all night. “Pollen can sit on your eyebrows, eyelashes, and in the nose, so rinsing off your face is super important,” says Gupta.

Consider a nasal rinse. Rinsing nasal passageways with a saline solution can flush out allergens and relieve sneezing, runny nose, and congestion.

Check pollen counts. Organizations such as the American Academy of Allergy, Asthma & Immunology’s National Allergy Bureau provide allergen reports detailing types of pollen and counts for different parts of the country.

Pollen reports can help you plan what precautions you need to take.
Stay inside during the mornings and when windy. Pollen counts are usually worse at these times, so it’s best to limit outdoor activities. Pollen counts are usually better after a rain storm.

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Nutrition, Benefits, Side Effects, More

Beef tallow has uses that expand beyond the kitchen. It can be used as part of a healthy skin-care regimen.

Beef Tallow Can Help Moisturize Skin

“Besides the greasy feel of beef tallow, there likely is little downside to using it on the skin. That being said, there certainly are more elegant and well-formulated moisturizers to get the job done,” says Joshua Zeichner, MD, an associate professor of dermatology and the director of cosmetic and clinical research in dermatology at Mount Sinai Hospital in New York City.

But beef tallow does contain the same types of fats that are found naturally in our outer skin layer, he acknowledges.

“By applying it to the skin, it provides emollient benefits to help soften rough cells on the skin’s surface and offer hydration benefits. So beef tallow could be a good option for people who are looking for completely natural solutions for their skin,” says Dr. Zeichner.

This might sound a little “out there,” but fats have long been used in skin care for their hydrating and emollient benefits, he says.

“It also may provide anti-aging benefits by repairing the skin barrier,” says Zeichner.

Beef tallow may be found as an ingredient in traditionally formulated moisturizers, or it can be used in its pure form directly from the supermarket.

Beef Tallow Won’t Help Treat Acne

Some people consider beef tallow to be a natural treatment for acne breakouts, says Zeichner.

“However, given the high levels of oleic acid in beef tallow, I don’t recommend that people use it for acne — oleic acid is a fatty acid known to block the pores. In general, people should stick to benzoyl peroxide as an acne treatment,” he says.

Beef tallow may be found as an ingredient in traditionally formulated moisturizers, or it can be used in its pure form directly from the supermarket.

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Could Ozempic and Other GLP-1 Drugs Treat Alcohol Use Disorder?

Popular weight loss drugs, like semaglutide (Ozempic, Wegovy) and liraglutide (Victoza), have transformed the way doctors treat diabetes and obesity . Now research suggests these meds — part of a class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) — may one day be a promising treatment for alcohol use disorder (AUD) . “The GLP-1 system seems to play a role in how and why some people develop problematic alcohol use and AUD,” says Lorenzo Leggio, MD, PhD , a physician-scientist with the National Institute on Drug Abuse and National Institute of Alcohol Abuse and Alcoholism in Baltimore. This system involves GLP-1 receptors, which are found in parts of the brain associated with addiction and reward.e60dc2a1-f33c-4a05-9b50-8e3e8e5976293bfa429b-5724-4364-b2cd-7104edb1c1ea AUD is a medical condition characterized by the inability to stop drinking alcohol, even if it causes health, job-related, or social problems. It affects nearly 29 million people in the United States ages 12 or older.e60dc2a1-f33c-4a05-9b50-8e3e8e5976297acb7aaa-c1e0-44af-bb1a-dcda9ef1b813 To date, the U.S. Food and Drug Administration (FDA) has approved only three medications to treat AUD: naltrexone, acamprosate, and disulfiram.e60dc2a1-f33c-4a05-9b50-8e3e8e5976294d86158c-df97-4cc7-a3f1-d4c33b9c3f42 While GLP-1 drugs could offer a welcome treatment option for people who struggle with alcohol addiction, the research is still in an early stage. Here’s what you need to know.
What Does Research Show About GLP-1 Drugs and Alcohol Use Disorder? What Research Shows Research on GLP-1 drugs for AUD and other substance use issues has gained momentum in recent years. “This is a time of cautious optimism in the field,” says Joseph P. Schacht, PhD , an associate professor of psychiatry and substance dependence at the University of Colorado School of Medicine Anschutz Medical Campus in Aurora. “Several small clinical trials have found that GLP-1 RAs, compared to placebo, reduced alcohol use,” he adds. Some of the most compelling research: In a study published in JAMA Psychiatry in February 2025 that included 48 patients with AUD, researchers found low-dose weekly injections of semaglutide significantly reduced alcohol cravings and nicotine use compared with placebo.e60dc2a1-f33c-4a05-9b50-8e3e8e597629a8ab3bad-deff-4e4d-bb0e-f619e6033e31 A report, published in the journal JCI Insight in May 2023, showed semaglutide reduced alcohol consumption and binge-like drinking in rodents. The effects were dose-dependent, meaning higher doses of semaglutide led to greater reductions in alcohol intake.e60dc2a1-f33c-4a05-9b50-8e3e8e5976292fefeb44-973c-4c5d-a6ba-2f26c4dbfe14 In a large Swedish study published in JAMA Psychiatry in November 2024, scientists found that people who were taking the GLP-1 drugs semaglutide or liraglutide were less likely to be hospitalized for AUD.e60dc2a1-f33c-4a05-9b50-8e3e8e59762925a53335-1e90-4165-b907-b8603da65e20 Early research has suggested that GLP-1s may also reduce cravings for other addictive substances, like cocaine.e60dc2a1-f33c-4a05-9b50-8e3e8e597629fe5fdb03-8721-47ae-b9f3-a04797b132f8 While these and other studies are encouraging, they’re still considered preliminary,” says Dr. Schacht. “Specific measures like safety, effectiveness, and dosing for AUD still need to be tested and confirmed. Ultimately, we need more data from larger clinical trials of these medications. Fortunately, multiple academic and industry trials should have results in the next one to two years.”
How Might GLP-1 Drugs Work for AUD? How They Work When it comes to weight loss, GLP-1 drugs work by mimicking a natural hormone in your body that controls appetite and blood sugar. This slows down how quickly food leaves your stomach, so you feel fuller longer and aren’t hungry as often.e60dc2a1-f33c-4a05-9b50-8e3e8e597629cf552d5b-b10f-4545-ae1d-da3d3caf3f3b Researchers don’t yet understand exactly how GLP-1 drugs work for AUD, according to Dr. Leggio. “Scientific evidence suggests that these mechanisms may be at least partially overlapping with those regulating food craving and food seeking,” he says. Schacht says there are several possible ways that GLP-1 drugs could affect alcohol cravings, including: GLP-1s might perceive alcohol as a caloric substance and affect it the same way it targets all calories you consume. But, Schacht notes, this wouldn’t explain why these drugs have an effect on non-caloric substances, like nicotine and cocaine. The medicines can cause unwanted gastrointestinal side effects, such as nausea, vomiting, and diarrhea, which might make someone less interested in drinking. As mentioned, GLP-1s may affect areas of the brain that underlie reward and motivated behavior. These areas are rich in dopamine, which helps control cravings for alcohol and drugs. But it’s unclear if medicines like semaglutide are able to access this part of the brain, notes Schacht. Further research is needed to help identify the exact link between GLP-1 drugs and reduced alcohol cravings.
Should I Ask My Doctor About GLP-1 Drugs for AUD? Should I Ask My Doctor? More research is still needed to determine if GLP-1 drugs are a safe and effective treatment for AUD. Until then, you might want to hold off on asking your doctor about GLP-1 drugs for AUD. “It’s too soon. Patients with AUD should discuss evidence-based treatments with their doctors,” says Leggio, who authored a commentary on this topic, published in the journal Nature in November 2023.e60dc2a1-f33c-4a05-9b50-8e3e8e597629651740d2-eed1-4bf9-868f-dcc949c6dbe4 If you’ve tried multiple other treatments with little to no success, it’s possible that your provider could prescribe a GLP-1 drug for AUD “off-label,” Schacht says. This means your doctor may recommend a medicine for a condition it hasn’t been approved by the U.S. Food and Drug Administration (FDA) to treat. “I am sympathetic to anyone who wishes to try a GLP-1 RA for AUD. Unfortunately, these medications are currently quite expensive, and insurance will not cover their use for AUD,” Schacht says. He adds that enrolling in a clinical trial could be another way to access these drugs for AUD.
What Are the Treatment Options for AUD? Treatments for AUD As mentioned, the three FDA-approved medications for AUD are:e60dc2a1-f33c-4a05-9b50-8e3e8e597629e3443b44-707a-485f-8c82-1e5c382095bb naltrexone (Vivitrol, Revia) acamprosate (Campral) disulfiram (Antabuse) Other treatment options for AUD include:e60dc2a1-f33c-4a05-9b50-8e3e8e597629e3443b44-707a-485f-8c82-1e5c382095bb Behavioral treatments: Behavioral interventions, like talk therapy or alcohol counseling led by a licensed therapist, are intended to help change drinking behaviors. Mutual-support groups: Mutual-support groups, such as Alcoholics Anonymous (AA) , are group meetings of peers who can provide each other with support for limiting or stopping drinking. They’re often low- or no-cost and are available in many communities in-person and online. The treatment that works best may vary from person to person. Some people may do well with brief interventions, for example, while others may need more intense behavioral treatments, medication, or both, says Leggio.
The Takeaway AUD affects more than 28 million Americans, yet there are only three FDA-approved medications to treat the disorder. GLP-1 drugs, which are currently FDA-approved to treat diabetes and obesity, may be a promising therapy for AUD in the future. More research needs to be done before doctors can safely prescribe GLP-1s for AUD. Until then, people with AUD should be prescribed standard, proven treatments.
Resources We Trust Mayo Clinic: Alcohol Use Disorder: Diagnosis & TreatmentCleveland Clinic: GLP-1 AgonistsNational Institute on Alcohol Abuse and Alcoholism: Understanding Alcohol Use DisorderAmerican Psychiatric Association: Alcohol Use DisorderMedlinePlus: Alcohol Use Disorder (AUD)

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What Happens at the First Appointment With a Rheumatologist?

Physical Examination

A physical exam is part of every first visit. Whether you keep your clothes on or change into a gown depends on your symptoms and the doctor, says Wolfe.

“Many rheumatologists will have every new patient get in a gown, because even if you think the problem is in your joints, it doesn’t mean that it’s not in other places. For example, we may find a rash, and so we want to check things out all over,” she says.

Sometimes it’s very clear what the issues are, and there’s no need to change into a gown, says Wolfe. If you think that’s the case, just make sure you’re dressed appropriately.

“If you’re coming in for your knees, this isn’t the time to wear skinny jeans. In general, it’s a good idea to wear stretchy clothes that aren’t too tight,” she says.

The physical exam usually includes the following:

  • Examining your joints.
  • Observing your movements, such as how you walk, bend, and grasp objects.
  • Looking for a rash or nodules (bumps) on your skin.
  • Listening to your chest for signs of inflammation in the lungs.

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Borderline Personality Disorder (BPD) vs. Schizophrenia: How They Differ

As mentioned, BPD and schizophrenia have several overlapping symptoms, including:

  • Difficulty maintaining close relationships
  • Feelings of paranoia
  • Episodes of psychosis

“Borderline personality disorder can consist of extreme emotional distress that appears like paranoia, which is very similar to the paranoia of schizophrenia,” says Ciara Bogdanovic, a licensed marriage and family therapist based in Los Angeles.

But as mentioned, BPD and schizophrenia have distinct differences, says Dr. De Gannes. The core symptoms of BPD center on emotional disturbance, while schizophrenia symptoms come from the disturbance of reality and thought, adds Bogdanovic.

“BPD often involves intense emotions, while schizophrenia can lead to pulling away from others,” Frank adds. “Emotional ups and downs and cognitive challenges are typical in both, though they stem from different causes.”

Although both conditions can lead to fractured relationships, the “why” varies by condition. In schizophrenia, confusion and hallucinations cause the most issues in relationships, says De Gannes. But in BPD, it’s the frequent switch between affection and anger, he adds.

Psychosis in BPD usually arises from extreme stress and is less common and severe than in schizophrenia, notes De Gannes.

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Head and Neck Cancer Signs and Symptoms

Head and neck cancers affect the tissues of the mouth, throat, sinuses, and surrounding areas. They can impact crucial functions like breathing, swallowing, and talking. There are several types of head and neck cancer, with nuanced symptoms. Noticing these symptoms and reporting them to your healthcare provider early can improve your treatment outcomes.
Symptoms of Head and Neck Cancer Symptoms A wide variety of less-serious conditions can mimic head and neck cancer symptoms. A sore throat that doesn’t improve is the most common symptom of head and neck cancers, and should be taken seriously.e60dc2a1-f33c-4a05-9b50-8e3e8e597629d4fd63c1-9ba3-4caa-b87e-1bfa491b1e4c Other head and neck cancer symptoms may include:e60dc2a1-f33c-4a05-9b50-8e3e8e597629bf968713-e58d-4293-b1b4-96c19c1f5855 A lump in the neck, jaw, or mouth Swelling under the chin or jawbone Sores or red or white patches in the mouth or the throat that won’t heal Difficulty or pain when swallowing Pain in the upper teeth or problems with dentures Pain in the face, neck, or chin that does not go away Unexpected paralysis of the face muscles An unexplained change in the voice or hoarseness Ear pain or hearing loss Frequent headaches Other less-common symptoms of head or neck cancer can include frequent earaches and a chronic sinus infection that doesn’t respond to antibiotics. Issues with the mouth, including unusual bleeding or numbness in the mouth or tongue could be signs of head or neck cancer.
Types of Head and Neck Cancer Types Head and neck cancers are categorized according to where the disease originates in the head and neck region. Most begin in the squamous cells that line the mucosal surfaces of the head and neck.e60dc2a1-f33c-4a05-9b50-8e3e8e5976293d22120e-5503-4b09-ba31-5f1def600325 Types of head and neck cancer include:e60dc2a1-f33c-4a05-9b50-8e3e8e59762928a52827-0bbd-4922-9129-682c654a18d9 Oral Cancer Oral cancer develops in the mouth and may affect the lips, tongue, cheek, and the floor or roof of the mouth. It’s one of the most common types of head and neck cancer.e60dc2a1-f33c-4a05-9b50-8e3e8e5976297a900af0-bf44-4ba9-83f4-431a7f22ccb6 Oropharyngeal Cancer This type of cancer occurs in the oropharynx , or the middle section of the throat. It may include the base of the tongue, tonsils, and back of the throat. Nasopharyngeal Cancer This rare type of cancer occurs in the nasopharynx , behind the nose and back of the throat. It’s often diagnosed in later stages. Hypopharyngeal Cancer This cancer forms in the hypopharynx, the lower part of the throat surrounding the larynx (voice box). Nasal Cavity and Paranasal Sinus Cancer These uncommon cancers occur in the nasal cavity or sinuses. Salivary Gland Cancer This rare cancer occurs in the salivary glands , including those near the mouth and jaw. It has multiple subtypes. Tonsil Cancer This is a subtype of oropharyngeal cancer that affects the tonsils and is often linked to HPV infection or tobacco use. The National Cancer Institute notes that cancer in other nearby areas, including the brain, the eye, the esophagus, the thyroid gland, and the skin of the head and neck are not usually classified as head and neck cancers.e60dc2a1-f33c-4a05-9b50-8e3e8e597629a175301d-ae5f-430e-9f5e-b46e0ccfe29f
When to See a Doctor Doctor’s Visits Detecting cancer early often leads to more successful treatment outcomes, so you don’t want to ignore any sign of a potential head and neck cancer. Although symptoms of head and neck cancer could be caused by many other things, if you have any of them, especially a chronic sore throat or a new lump in the head or neck, it’s important to ask your doctor about the possibility of cancer. You should also talk to your dentist about any issues with your mouth besides your teeth, including pain, swelling, or unexplained bleeding, that could be signs of cancer or other problems.e60dc2a1-f33c-4a05-9b50-8e3e8e597629f0086d15-c5b4-4259-b4ae-2b022337069c Your doctor is likely to examine the head and neck area to feel for abnormalities and may use mirrors and lights inside the mouth and throat to explore areas that are harder to see. Blood or urine tests may also be performed. If your doctor or dentist thinks there is a possibility of head or neck cancer, you may be referred to a specialist like an otolaryngologist for a more comprehensive examination.e60dc2a1-f33c-4a05-9b50-8e3e8e5976293c317ca6-14fd-42b8-8974-099928e96cb2 Some common tools for helping diagnose head and neck cancer include:e60dc2a1-f33c-4a05-9b50-8e3e8e597629ed49f5c9-0101-48f7-bcca-8727de91966a Endoscopy This thin lighted tube with a camera at the tip can help a doctor explore areas of the head and neck, including the sinuses, that are harder to reach. Diagnostic Imaging A radiologist can take images of your throat that may include CT scans, PET scans, MRIs, or an X-ray called a Panorex (panoramic radiograph) that shows the upper and lower jaw and the sinuses. Biopsy A surgeon may remove a small amount of tissue from an area where cancer is suspected. A pathologist examines the sample and consults with team members to make a diagnosis. If there is a diagnosis of cancer, your doctor will consult with you to determine the best options for treating the cancer, based on its location and how far it has progressed.
The Takeaway Head and neck cancer is a group of cancers that develop in the tissues of the head and neck, including the mouth, throat, sinuses, and salivary glands. Early detection of head and neck cancer is crucial for better outcomes, and symptoms can sometimes be mistaken for those of other conditions. Common signs include persistent lumps, sores that don’t heal, difficulty swallowing, voice changes, and unexplained pain. If you notice these signs and symptoms, especially sore throat or a new lump in the head or neck, talk to your doctor immediately.
Resources We Trust Mayo Clinic: What is mouth cancer? A Mayo Clinic expert explains Cancer Care: Coping With Oral and Head and Neck CancerHead and Neck Cancer Alliance: Oral, Head & Neck Self-Exam GuideSupport for People With Oral and Head and Neck Cancer: Find a Local Chapter Near YouMemorial Sloan Kettering: Resources for Head and Neck Cancer Survivors

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