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An eco-friendly toxic cocktail could be a new weapon against malaria

Female Anopheles drinks a pink cocktail containing beetroot juice and HMBPP. Credit: Melika Hajkazemian

Mosquitoes can eat beetroot juice supplemented with HMBPP. This is the result of a study at Stockholm University. HMBPP is a metabolite produced by Plasmodium malaria. Researchers have shown that adding HMBPP supplements and protein / lipid mixtures to plant juices, especially beetroot juices, can mimic blood meals to the extent that mosquitoes naturally prefer this artificial solution.

Mosquitoes can be fooled into adding toxins to feed a beetroot-based mix. The researchers tested four toxins, including capsaicin, perfume oil, boric acid, and fipronil sulfone (an insecticide), and compared them to a control diet. The tendency to land and consume pesticide cocktails was consistent with a non-toxic diet, resulting in the death of all tested mosquitoes within 100-350 minutes after feeding.

“This mixture, which we call pink juice, is a harmless, inert and environmentally friendly solution, but it is naturally toxic. Female mosquitoes Noushin Emami, an associate professor of molecular biology science at Stockholm University, says when they ingest:

“Overall, here we provide a proof of concept for a special, environmentally friendly feeding trap that can be deployed as needed. We expect it to be tested in field settings in combination with other vector control approaches. “.” Nushin Emami.

Nusin Emami’s group is studying mosquitoes Blood meal Ingestion and certain attractants and stimulants. The appetite stimulant HMBPP aims to eradicate mosquito-borne diseases by altering mosquito behavior and allowing specific control of mosquito populations.Being able to target only blood-seeking species mosquito At the same time, not affecting other organisms is paramount in an era of global biodiversity decline, pesticide health hazards, and new pesticide resistance.

“There are several new and exciting high-tech approaches to invading mosquitoes. Large-scale test However, there are many things to do to develop a very simple yet very effective solution using materials that are not only affordable but also accessible to most people, based on simple molecules. I think there is a possibility of. This study used beetroot to show this very point. “Noushin Emami says.

Background

For the past 1.5 years, the viral COVID-19 pandemic has dominated headlines around the world. From 2015 to 2016, the Zika virus epidemic was worried by scientists, global health professionals, and the general public. The SARS-CoV-2 virus floats in the air, while the Zika virus spreads through mosquito vectors. It is not the only pathogen that uses these flying, lively, chewing insects to spread to new species and geographic locations. Another mosquito-borne pathogen is the chikungunya virus, Dengue virus, Malaria (Plasmodium malaria) parasites, etc. The latter two pathogens alone claim more than 300 million cases and 440,000 deaths annually.

In the study, mosquitoes straddling An. coluzzii, An. Arabiensis, Anne. gambiae ss, An. gambiae sl, Ae. Aedes aegypti and Culex pipiens / Trentium species in Europe have been found dead.


Eating sugar can infect mosquitoes and impede their ability to infect arboviruses


For more information:
Viktoria E. Stromsky et al, Plasmodium metabolite HMBPP, stimulates feeding of major mosquito vectors to blood and artificial toxic sources. Communication biology (2021). DOI: 10.1038 / s42003-021-02689-8

Quote: Eco-friendly toxic cocktails, malaria obtained on October 12, 2021 from https: //medicalxpress.com/news/2021-10-eco-friendly-toxic-cocktail-weapon-malaria (October 2021) May be a new weapon against (12th) .html

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