Health

20% of multi-drug-resistant tuberculosis cases in children could be averted by household testing and treatment

An unseen digital image of Mycobacterium tuberculosis tuberculosis. Credit: CDC NIAID

One in five cases of tuberculosis (MDR) tuberculosis (TB) in children under the age of 15 can be eliminated each year through family planning, according to a new product study published in Lancet Global Health.

Research from the London School of Public Health and Medicine (LSHTM), University of Sheffield and Imperial College London, suggests this trial and treatment strategy could eliminate 3,950 deaths and 5,870 deaths in children under 15 years of age.

Conduct consultations, which include working with TB patients to encourage their partners to diagnose tuberculosis and fetuses vaccine for those who qualify, they are not implemented as often as they should. The reasons for this are complex. In many countries with limited resources, Home contact care is not seen as a priority, because most tuberculosis programs are more focused on caring for TB patients who have symptoms and are going to health facilities. In addition, the guidelines for how to conduct MDR-TB contact wells are inaccurate and based on limited evidence.

Researchers say that this study could be a turning point in demonstrating the effectiveness of this approach in terms of its low cost and high effectiveness in preventing disease and death.

Dr Finn McQuaid, Associate Professor at LSHTM and co-author of the study said: “Children are a separate group in the management of tuberculosis and are very sensitive to MDR-TB. “No one can make a significant impact. Our work shows that these activities can have a significant impact in many countries.”

Recent WHO estimates that more than one million children are infected with tuberculosis each year, but only about half are diagnosed and treated. Nearly a quarter of children with tuberculosis die; almost all of these have not been identified, making tuberculosis the leading cause of death in children. Of the estimated 30,000 people infected with MDR-TB, only about 15% are diagnosed, with those who are untreated and at risk of death. However, if properly treated, the results of MDR-TB are very positive.

The exact figures for the prevalence of tuberculosis and tuberculosis at home are unknown, but estimates range between 10% and 30%, with no MDR-TB data available. This may increase the risk of COVID-19 infection, with more time spent at home and fewer people being diagnosed. The number of cases as a result of domestic transmission is significantly reduced for adults.

The study used a statistical analysis to look at the impact and cost of 213 countries identifying children with MDR-TB infection to see if they had tuberculosis, and providing vaccines to non-TB partners. they are infected but they risk developing it.

Dr. McQuaid said: “This paper can provide guidance to policy makers who may choose anti-tuberculosis drugs, such as consulting with each other and providing antibiotics, considering the type of treatment to be given and to which. shows how the significance of these things changes through setting. “

Dr. James Seddon, a reader at Global Child Health at Imperial and one of the study’s authors, adds: “International and national decision-makers can use our research to make recommendations for improvement, and most targeted and appropriate interventions when it comes. home care for MDR-TB and antibiotics. “

As the first recipients of tuberculosis vaccine, this study is limited to children. However, the high cost of MDR-TB treatment means this message can be expensive for adults too.

Dr. Seddon said: “I would like to see donors for research and national tuberculosis programs using this study to encourage further research to determine whether local MDR-TB management can be effective. a useful tool to reduce the incidence of MDR-TB in children. “

The authors acknowledge the shortcomings of the study, including the fact that the effect of interventions on the spread of Mycobacterium tuberculosis has not been considered. This will further increase the benefits and cost savings. The study did, however, take a higher coverage, which is practically impossible.


Children, adults can transmit SARS-CoV-2 to local partners


Learn more:
Peter J Dodd et al, Global Impact on Consulting Home for Children on Multiple Tuberculosis and rifampicin, mortality, and health care costs in 2019: a case-control study, Lancet Global Health (2022). DOI: 10.1016 / S2214-109X (22) 00113-9

hint: 20% of multidrug-resistant tuberculosis in children can be eliminated by home trial and treatment (2022, May 20) returned May 20, 2022 from https://medicalxpress.com / news / 2022-05-multi-drug- resistant-tuberculosis-cases-children-hautar.html

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20% of multi-drug-resistant tuberculosis cases in children could be averted by household testing and treatment Source link 20% of multi-drug-resistant tuberculosis cases in children could be averted by household testing and treatment

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